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In the Pipeline - Nov 13, 2008
Organic chemisty can be a real high-wire act. If you’re taking a compound along over a multistep sequence, everything has to work, at least to some extent: a twelve-step route to a compound whose last step can’t be …
In the Pipeline - Nov 5, 2008
About a year ago I wrote a post on flow chemistry. That, broadly speaking, is the practice of doing reactions by pumping them through some sort of reaction zone, instead of putting everything into a flask and letting …
In the Pipeline - Oct 28, 2008
I’ve noticed over the years that my patience in seminars and talks has been eroding. This started in graduate school – I certainly sat through my share of lousy talks back then, but I was starting to skip out on the …
In the Pipeline - Oct 20, 2008
It’s worth examining your own scientific prejudices and biases from time to time, to see if they’re still valid. Of course, that begins with the difficult task of figuring out what they are – it’s hard to think of …
In the Pipeline - Oct 13, 2008
We try to be delicate when we synthesize our molecules – really, we don. Delicate reactions often have better yields and fewer side products. Exotic catalysts in perfectly tuned metal coupling reactions – these things …
In the Pipeline - Sep 29, 2008
For the most part, the biologists on a drug discovery project expect us in the med-chem labs to be able to make pretty much anything we need to make. Actually, I don’t have to go that far – the other chemists more or …
In the Pipeline - Sep 17, 2008
I did carbohydrate chemistry for my PhD - well, I used carbohydrates as starting materials to make other molecules, but I did my share of pure carbohydrate stuff along the way. And although that was over twenty years …
In the Pipeline - Aug 19, 2008
I wanted to recommend this post by Milkshake over at Org Prep Daily (and not just because he liked the recent column I wrote for Chemistry World). I was writing about the limited number of reactions that some med-chem …
In the Pipeline - Jul 28, 2008
1. “Hey, who dropped that condenser out on the floor in front of my hood? That looks just like the one I had on my reaction flask. . .” 2. “How come the toxicology people haven’t called me about our lead compound yet? …
In the Pipeline - Jul 21, 2008
One of the things that no one realizes about research (until they’ve done some) is how much time can be spent going back over things. Right now I’m fighting some experiments that should be working, have worked in the …