Speeple News Search

Sign Up! | Tags | Domains | Statistics | Options | Advanced Search

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

nature.com » 2009 » March » 16th » Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

In this issue, three reports show that Kindlin-3 is crucial for activation of multiple classes of integrins in several types of hematopoietic cells. In mice, Kindlin-3 was previously shown to be important for platelet activation and blood clotting, and Moser et al. now show its importance in leukocytes for adhesion to the endothelium. In humans, Svensson et al. and Malinin et al. show that … Continue Reading »

Latest news from Nature Medicine - Issue - nature.com science feeds:

  1. A cure for cancer research
  2. After Avandia, some seek split in drug approval and monitoring
  3. Chronic controversy continues over mysterious XMRV virus
  4. Fewer shots proposed to increase uptake of HPV vaccine
  5. Fight for subject confidentiality threatens disaster research

Latest news from nature.com:

  1. Green with underappreciation
  2. Solid-state NMR and SAXS studies provide a structural basis for the activation of αB-crystallin oligomers
  3. Double-stranded RNAs containing multiple IU pairs are sufficient to suppress interferon induction and apoptosis
  4. An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein
  5. Molecular basis of FIR-mediated c-myc transcriptional control